Ibuprofen and Infertility in Men Linked by Study

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A research team gathered male volunteers between the ages of 18-35, and gave them daily doses of ibuprofen.

The new study isn't the first to suggest that ibuprofen has downsides. Epidemiological studies have shown that NSAID exposure was associated with reduced testosterone and congenital malformations; another study showed a drop in a testosterone metabolite among men who were taking ibuprofen regularly. It didn't take long - just two weeks - for the drug to disrupt the hormonal balance and rate of testosterone production of these men.

The researchers found that prolonged ibuprofen use suppressed "important aspects of testicular function, including testosterone production".

While the study sample was a relatively small one, the researchers noted that its findings have been independently confirmed from isolated cells, and earlier studies had suggested potential issues with men's sexual health and the drug.

Scientists warn that ibuprofen could be wrecking men's fertility by making their balls shrivel up.




The human brain compensates for testosterone deficiency by producing luteinizing hormone (LH), which sends a signal to the testicles to produce more testosterone. That works out to three ibuprofen tablets per day if you're taking a typical 200mg/tablet product. Under the condition, which is normally seen in smokers and older men, the body needs to boost testosterone production because normal production inside the testes has declined.

In addition to limiting fertility, ibuprofen or NSAIDS, may increase the risk of heart attack or stroke. Before he stepped down in November 2016 he asked players about their use of over-the-counter painkillers and found that almost half of those who played in the past three World Cups took anti-inflammatory drugs, such as ibuprofen, every day.

"The safety and efficacy of active ingredients in these products has been well documented and supported by decades of scientific study and real-world use", said Mike Tringale, a spokesman for the association, according to Fox News.

The research, which was published in the Proceedings of the National Academy of Sciences journal, showed that the men who took the high doses of ibuprofen developed the disorder known as compensated hypogonadism. In both cases, ibuprofen had a direct effect on the testicles.

"Our immediate concern is for the fertility of men who use these drugs for a long time", researcher David Møbjerg Kristensen from the University of Copenhagen in Denmark told The Guardian.

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