African-American men with prostate cancer show stronger response to hormone therapy

Jeff Stelling promotes Prostate Cancer UK's Men United campaign

Now, a new study led by The Institute of Cancer Research and the Royal Marsden Hospital in London has found "amazing" results in those with prostate cancer.

FRIDAY, June 1, 2018 (HealthDay News) - Black men with advanced prostate cancer who get chemotherapy may live longer than white men, a new study suggests. However, numerous men who were at death's door have been on the drug for more than 18 months and show no signs of the disease'.

Researcher Professor Johann de Bono commented on the findings: "This is the first evidence that a subset of prostate cancer patients do spectacularly well on immunotherapy".

Prostate cancer patients with weeks or months to live could survive longer after undergoing immunotherapy treatment, a major trial has shown.

Prostate expert Dr David Graham at Levine Cancer Institute, North Carolina, said: 'These men have the most aggressive type of disease and have been through the gamut of what we have available now. We have several patients in the Marsden who have had a complete response.




Nonetheless, for sufferers reminiscent of these within the new examine with docetaxel-refractory metastatic castration-resistant prostate most cancers, there may be at present no efficient therapy. The amount of damage that a cell can endure, however, is influenced by external factors such as alcohol, smoking, exposure to UV light, and many cancer cells have lost some of the ability to self-repair the genome.

Just 5 percent of men in the trial saw their tumours actually shrink or disappear after treatment, but the proportion was higher in a small group of men whose tumours had mutations to genes involved in repairing DNA, the researchers noted.

They stop cancers turning off the immune system so the body can keep on attacking the tumour. It has already been shown to be highly effective in tackling other forms of the disease, including skin and lung cancer. More white patients than black patients had no PSA decline. "This new trial has found that testing for mutations in DNA fix genes could be valuable marker of who will respond".

If patients who can respond to immunotherapy are identified, some of them may be able to avoid treatments that come with unwanted side effects.

"If we can prove that in the planned new trial, it should be possible to provide some men with advanced prostate cancer with an exciting new treatment option". In addition, they are more likely to be diagnosed at a younger age and with advanced, aggressive cancer, the researchers said.

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